Hello Nate,
Thanks for sharing the Cell article. AMPK seems to be one of the key indicators for mitochondrial functioning. We haven't tested it directly, but we might infer that Strong Endurance style training would increase mitochondrial functioning and biogenesis.
Here are some more great articles:
Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002). AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proceedings of the National Academy of Sciences, 99(25), 15983–15987.
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
Chilibeck, P. D., Syrotuik, D. G., & Bell, G. J. (1999). The effect of strength training on estimates of mitochondrial density and distribution throughout muscle fibres. European Journal of Applied Physiology and Occupational Physiology, 80(6), 604–609.
The effect of strength training on estimates of mitochondrial density and distribution throughout muscle fibres
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006). Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. The Journal of Physiology, 576(Pt 2), 613–624.
https://doi.org/10.1113/jphysiol.2006.113175
Daussin, F. N., Zoll, J., Ponsot, E., Dufour, S. P., Doutreleau, S., Lonsdorfer, E., … Richard, R. (2008). Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle. Journal of Applied Physiology, 104(5), 1436–1441.
https://doi.org/10.1152/japplphysiol.01135.2007
Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M. (2009). Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle. Journal of Applied Physiology, 106(3), 929–934.
https://doi.org/10.1152/japplphysiol.90880.2008
Little, J. P., Safdar, A., Bishop, D., Tarnopolsky, M. A., & Gibala, M. J. (2011). An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 300(6), R1303-1310.
https://doi.org/10.1152/ajpregu.00538.2010
Wang, L., Mascher, H., Psilander, N., Blomstrand, E., & Sahlin, K. (2011). Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle. Journal of Applied Physiology (Bethesda, Md.: 1985), 111(5), 1335–1344.
https://doi.org/10.1152/japplphysiol.00086.2011
Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., … Musi, N. (2007). Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study. Diabetes, 56(3), 836–848.
https://doi.org/10.2337/db06-1119