One major thing I recommend doing beyond many of those already mentioned (like prioritizing sleep, exercise, and clean eating) is to work with a functional medicine doctor to do all the necessary screens (a physical, prostate exam, colonoscopy, comprehensive metabolic panel + Cardio IQ lipid panel, carotid ultrasound, coronary artery calcium scan if needed, etc.). She/he can then customize an approach that's specific to you, with routine assessments/tests to gauge progress.
It's one of the best things I've done, and I'm pretty convinced it will pay the highest dividends vs. spending hundreds of dollars on supplements I don't even know are helping. I also see a holistic/integrative dentist for the same reason, and it was the first time I've actually had the bacteria in my mouth examined for specific treatment options.
Consider using a continuous glucose monitor, DNA analysis, an Oura ring or Whoop for sleep and activity, a home BP monitor, etc. for more tracking options for yourself and for your care team.
The hard data is just super important - of course, we're learning more every day, so it's important to find a forward-thinking, longevity-focused functional medicine or naturopathic doc who is up on the latest research and will adjust your plan as needed.