@North Coast Miller your a better man then I. I've done Push/Pull and upper/lower splits before and I have been toasted on a 4 day week (Push, Pull, Rest, Push, Pull, Rest, Rest) Especially if I'm squatting on my push/lower days. added muscle though.
I get my best hypertrophy results from even more detail oriented breakdown on a 6 day week, but find that just isn't really practical anymore - no time and not enough equipment.
Over the Summer I got some solid results doing push/hinge and pull/squat alternating days - 3-4 times a week. But I did break down the sets just like Thibaudeau describes, using mostly rest/pause but some drop sets if I wasn't hitting at least 6 reps. Also used the slow eccentric. Training to technical failure at least one set per lift where appropriate is also helpful. To me, rest/pause and drop sets are variations of training to failure, not much different than getting a spot on the concentric although not quite as effective either.
I've learned from past mistakes and overtraining, to limit my workout to 40 minutes absolute max and better at 30. Reduce rest periods to get the volume in a shorter period, and in my case some extra fruit an hour/45 minutes prior to the workout makes a big difference.
I currently have no opinion on muscle damage/metabolic stress and whether it is needed (the qualified success of Blood Flow Restriction training would seem to indicate a proof-positive effect to some extent). If you compress the workout you will become more acidic, but your clearance rates improve by training in this manner, and your lactate threshold goes up as well - tho at higher intensity you are liable to blow right past it anyway.
Another factor in my opinion, is that much of the metabolic stress/overtraining/wiped out feeling is from not eating to the workout. Pretty sure I've mentioned this before, but when I was much younger and much more serious about this, my lifting diet was markedly different from an off-day diet. If I had to cancel my workout at the last minute I'd have real trouble getting to sleep that night - those being 1-1.5 hour sessions 5-6 days a week. When I got back into the fitness microcosm, I was surprised to learn that based on contemporary thought I should have felt like poop training the way I did, as I had never felt better in my life before or since.
Ultimately I feel periodizing for hypertrophy is the best way to go about it unless it is a primary goal, and these periods can be as brief as 25% of a larger strength-based routine, as short as 2-3 weeks per.