mTOR Signaling & Growth (Mammalian Target of Rapamycin)

ali

Quadruple-Digit Post Count
Research indicate the Ketogenic Diet protects and spare Leucine from being used for fuel. Source: The Art and Science of Low Carbohydrate Performance, Volek and Phinney
That's a worthwhile tweak.....

Additional research show that the amino acid, Alanine is converted to glucose, sparing Leucine.
And as it is converted to glucose, why not use the protein for protein and have a banana for the ready made glucose?

Kenny...we are almost in agreement...you have workaround hacks for your specific needs....which are solidly researched and applied.
But for others unnecessary if their health is not compromised.
I'm of the 'earn your carbs' view as a simple framework.
There is value to that....using insulin to store glucose post training with mTor and glut4 non-insulinogenic transporters being online too. For an insulin sensitive person this is a really easy strategy. And at other times, less starch and fast acting glucose is minimised.
That's about it for me. No calorie counting, no shakes and what not. Just good food. I try to eat more protein from mixed sources after training but that's all I do. And sometimes not for 2 hours.
If anything I seek to optimise is my response to stress and sleep, then food and cooking. Stressed and undersleeping creates an uphill struggle. Crack that, nutrition sort of becomes optimised without any real intent.
 

HUNTER1313

More than 500 posts
In the new article about Pavels new book he says intermittent fasting, caloric restriction , and cold is good for us. If this is true and it's said you can build muscle on this new program, doesn't that fly in the face of having to have the leucine pulses?
 

kennycro@@aol.com

Quadruple-Digit Post Count
In the new article about Pavels new book he says intermittent fasting, caloric restriction , and cold is good for us. If this is true and it's said you can build muscle on this new program, doesn't that fly in the face of having to have the leucine pulses?
No

Your interpretation of this information amounts to viewing being more productive by avoid sleep and relaxation (playtime) and constantly focus on work.

It doesn't work that way.

Intermittent Fasting and Calorie Restriction

These methods provide for some heath benefits. Essentially, they allow the body to take out the garbage.

However, Intermittent Fasting and Calorie Restriction is not anabolic.

As Dr Jose Antonio basically stated, "Eating is anabolic"; increasing muscle mass and at time body fat, dependent on your diet.

Cold and Heat

Cold and Heat place stress on the body producing "Heat Shock Proteins" which assist with recovery.

Leucine and Exercise

Two of the main reasons individual lose muscle mass is due to not consuming enough protein (Leucine) per meal/serving and not exercising.

This is especially true with older individual. Research determined that "Pulse Feeding" enabled them to maintain and in some instance increase muscle mass by consuming higher protein intake in Leucine rich foods.

Excellent Podcast On This

1) Dr Donald Layman: Protein Metabolism

2) Dr Gabrielle Lyon: Muscle Growth Science, mTOR & Leucine

3) Dr Keith Baar: mTor Signaling & Cell Growth: Targeting via Ketogenic Diet & Fasting

"For everything there is a season, and a time for every purpose under heaven..."
Ecclesiastes

This same applies to...

1) Refractory Eating: Eating every 4 - 6 hours which optimizes Muscle Protein Synthesis.

2) No snacking between meals.

3) Consuming the right amount of Leucine with each meal to trigger mTOR, an anabolic effect.

5) Periodization Training Programs that provides for Active Recovery.


Kenny Croxdale
 
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LukeV

More than 300 posts
I like to drink coffee in the morning and beer at night, both of which I understand inhibit mtor. Does anyone know how long I should wait after consuming coffee or alcohol before ingesting Leucine to trigger mtor?
 
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