Snowman
Level 6 Valued Member
Only if you're living in a sterile environment without physical demands . MTor is critical for immune function and tissue maintenance. For mice living in sterile cages, with no physical demands, that doesn't make much of a difference. For real humans in real life, it's kind of important.I thought the thing with Mtor was to limit it? For longevity, that is.
Honestly, I feel like this whole mTor thing is just blown out of proportion. You don't want it turned on all the time. But you do want it turned on occasionally. Just like every other thing in the human body. Almost nothing in physiology is optimized in a steady state. Pulsatile activation is key, with everything from growth hormone production to myocardial contractions. MTor ain't special. Turn it on occasionally, but don't keep it on. How do you do that? I dunno, maybe with a healthy diet and exercise, like people have been doing forever.
The mTor cancer mice had a genetic variant that kept mTor on all the time, which is why they got cancer. It's extremely difficult to mimic that level of activation with protein. Actually, the only way to keep the switch turned on [almost] all day is by relying on another molecule that activate mTor even better than protein. Any guesses? Insulin. Insulin turns on mTor in a big way, one of the many reasons it's an effective PED for bodybuilders. So ironically, the people who limit protein and increase carbs in an effort to limit constant mTor activation might be doing the opposite, if their insulin levels are remaining elevated through the day. Better to just eat your damn protein in discreet servings a few hours apart [EDIT: at least a few hours apart. As in, not constantly], so mTor can turn on and then turn off again, like it's supposed to.
There is nothing new under the sun...
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