As maybe a final thought on this, my experience def leads me to believe there must be some lactate accumulation to trigger notable muscle synthesis.
Reps closer to fatigue failure (either single strings of reps or multiple single or low number of reps performed with brief rest - Rest/Pause, Myo Reps, Clusters) generate very large spikes in lactate as the glycolytic pathway mostly being used to power type2 fibers, and increasing metabolic interference with contraction force of those fibers.
The increase in lactate combined with local muscle damage from tension and (possible contributing role) specific fiber depletion of glucose are potent signalling pathways. They can be achieved a number of ways, but most easily with eccentric overload and lactate accumulation.
I suspect something of a linear dose response in a fairly narrow range, with less stimulus falling off the low end and more stimulus flatlining or even reducing the response.
Pathophysiology of Exercise-Induced Muscle Damage and Its Structural, Functional, Metabolic, and Clinical Consequences
The effects of lactate on muscle mass and regeneration were investigated using mouse skeletal muscle tissue and cultured C2C12 cells. Male C57BL/6J mice were randomly divided into (1) control, (2) lactate (1 mol/L in distilled water, 8.9 mL/g body weight)-administered, ...
www.ncbi.nlm.nih.gov