Kenny Croxdale
Level 7 Valued Member
Cliff Notes of mTOR Signaling & Growth (Mammalian Target of Rapamycin)
Podcast https://hvmn.com/podcast/mtor-signaling-&-cell-growth-ft-dr-keith-barr-ep-109
The first 36 minutes of the podcast is about mTOR.
1) mTOR signals and promotes muscle growth.
a) Exercise triggers mTOR, muscle growth.
b) Leucine (amino acid) in the right amount promotes muscle growth via mTOR.
c) Leucine elicits mTOR in a different way than Exercise.
d) "...If you only have one, you only get part of the response."
c) Exercise with the right amount of Leucine elicits a synergistic (additive) effect; Kenny's metaphoric analogy, 2 + 2 + 5!
2) AMP-k, Activated Protein Kinase
a) AMP-k inhibits mTOR
b) Low glucose, Fasting and the Ketogenic Diet activate AMP-k.
3) Increasing Life Span
a) Low Carbohydrate Diets increase Life Span 6%
b) Ketogenic Diet increase Life Span 13%
c) "...The increase in lifespan the result of the ability to inhibit baseline mTOR activity."
d) "mTOR is really important for cancer growth."
e) "...What happens as we begin to age, ... Baseline inflammation goes up. ...What the ketogenic diet does, it keeps the baseline down."
3) Maintaining Low mTOR Baseline For Health
Extrapolated information from the podcast...
a) Chronic elevation of mTOR promotes heath issues.
b) Low Carbohydrate Diets, Fasting and the Ketogenic Diet maintain a low mTOR Baseline; promote health.
4) Acute Elevation of mTOR For Strength/Increasing Muscle mass
a) Acute/short spikes of mTOR increase Strength/Muscle Mass.
b) Exercise specifically "Targets" the activation of mTOR to the muscles worked. Leucine or Leucine rich proteins consumed are shuttle directly to the muscles trained.
c) When Leucine or a Leucine rich proteins are consumed without Exercise; Leucine has a "Global Growth Effect". Growth of all cells are promoted, like cancer
6) Increasing Some Muscle Mass While Decreasing Other Muscle Mass For Sports
1) British "Sky City" Cycling's Program
a) ..."They want to get rid of the upper body. They want to maintain legs, because that increases power to weight ratio."
b) "...Give them a very low caloric diet. ...Have them take all of their calories in around their exercise, ...give them all calories that are gonna be leucine rich proteins, so that it's gonna be targeted to the muscle that we want to maintain. ...They maintained leg strength, leg size, in an individual who had a 3 to 4 kilo loss in upper body mass. So you waste the upper body mass, because you don't need it, and then you maintain the lower body mass by using the exercise as a way to target the nutrients."
"...You target by using exercise as a targeting device."
"...If I do an exercise session, and I take it (Leucine) right afterwards, and I've got lots of blood flow going to the muscles they just worked, what you've basically done is you've taken an envelope that you've put into the mail, and you've put an address on it. So same nutrients, same supplement, but now by using blood flow that I've done, I've targeted to the muscles I want to target by using exercise, now everything that I just took in is going to go to the place that I want it to go."
"It's the same thing that Lance Armstrong did during his cancer rehab. So, he was getting chemotherapy, he was taking in calories, and he was cycling through this. So as he was cycling, he had been a triathlete, he had been a guy with big upper body, big back, big shoulders. And then as he's cycling with chemotherapy, the chemotherapy and the nutrients are all getting targeted to his muscles of his legs, so he maintains. The chemotherapy targeted him and he lost a huge amount of upper body mass. And it was a lot of muscle mass that he lost. And so that increases power to weight ratio and gave them this great advantage."
7) Nutrient Timing Window For Leucine/mTOR
...It's not that there's a window where you have to get in within a certain amount of time. Because the window is quite big and it's quite open.
Kenny Croxdale
Podcast https://hvmn.com/podcast/mtor-signaling-&-cell-growth-ft-dr-keith-barr-ep-109
The first 36 minutes of the podcast is about mTOR.
1) mTOR signals and promotes muscle growth.
a) Exercise triggers mTOR, muscle growth.
b) Leucine (amino acid) in the right amount promotes muscle growth via mTOR.
c) Leucine elicits mTOR in a different way than Exercise.
d) "...If you only have one, you only get part of the response."
c) Exercise with the right amount of Leucine elicits a synergistic (additive) effect; Kenny's metaphoric analogy, 2 + 2 + 5!
2) AMP-k, Activated Protein Kinase
a) AMP-k inhibits mTOR
b) Low glucose, Fasting and the Ketogenic Diet activate AMP-k.
3) Increasing Life Span
a) Low Carbohydrate Diets increase Life Span 6%
b) Ketogenic Diet increase Life Span 13%
c) "...The increase in lifespan the result of the ability to inhibit baseline mTOR activity."
d) "mTOR is really important for cancer growth."
e) "...What happens as we begin to age, ... Baseline inflammation goes up. ...What the ketogenic diet does, it keeps the baseline down."
3) Maintaining Low mTOR Baseline For Health
Extrapolated information from the podcast...
a) Chronic elevation of mTOR promotes heath issues.
b) Low Carbohydrate Diets, Fasting and the Ketogenic Diet maintain a low mTOR Baseline; promote health.
4) Acute Elevation of mTOR For Strength/Increasing Muscle mass
a) Acute/short spikes of mTOR increase Strength/Muscle Mass.
b) Exercise specifically "Targets" the activation of mTOR to the muscles worked. Leucine or Leucine rich proteins consumed are shuttle directly to the muscles trained.
c) When Leucine or a Leucine rich proteins are consumed without Exercise; Leucine has a "Global Growth Effect". Growth of all cells are promoted, like cancer
6) Increasing Some Muscle Mass While Decreasing Other Muscle Mass For Sports
1) British "Sky City" Cycling's Program
a) ..."They want to get rid of the upper body. They want to maintain legs, because that increases power to weight ratio."
b) "...Give them a very low caloric diet. ...Have them take all of their calories in around their exercise, ...give them all calories that are gonna be leucine rich proteins, so that it's gonna be targeted to the muscle that we want to maintain. ...They maintained leg strength, leg size, in an individual who had a 3 to 4 kilo loss in upper body mass. So you waste the upper body mass, because you don't need it, and then you maintain the lower body mass by using the exercise as a way to target the nutrients."
"...You target by using exercise as a targeting device."
"...If I do an exercise session, and I take it (Leucine) right afterwards, and I've got lots of blood flow going to the muscles they just worked, what you've basically done is you've taken an envelope that you've put into the mail, and you've put an address on it. So same nutrients, same supplement, but now by using blood flow that I've done, I've targeted to the muscles I want to target by using exercise, now everything that I just took in is going to go to the place that I want it to go."
"It's the same thing that Lance Armstrong did during his cancer rehab. So, he was getting chemotherapy, he was taking in calories, and he was cycling through this. So as he was cycling, he had been a triathlete, he had been a guy with big upper body, big back, big shoulders. And then as he's cycling with chemotherapy, the chemotherapy and the nutrients are all getting targeted to his muscles of his legs, so he maintains. The chemotherapy targeted him and he lost a huge amount of upper body mass. And it was a lot of muscle mass that he lost. And so that increases power to weight ratio and gave them this great advantage."
7) Nutrient Timing Window For Leucine/mTOR
...It's not that there's a window where you have to get in within a certain amount of time. Because the window is quite big and it's quite open.
Kenny Croxdale
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